Adipose-Derived Stem Cells in Cancer Progression: New Perspectives and Opportunities.

ABSTRACT: Growing importance has been attributed to interactions between tumors, the stromal microenvironment and adult mesenchymal stem cells. Adipose-derived stem cells (ASCs) are routinely employed in regenerative medicine and in autologous fat transfer procedures. To date, clinical trials have failed to demonstrate the potential pro-oncogenic role of ASC enrichment. Nevertheless, some pre-clinical studies from in vitro and in vivo models have suggested that ASCs act as a potential tumor promoter for different cancer cell types, and support tumor progression and invasiveness through the activation of several intracellular signals. Interaction with the tumor microenvironment and extracellular matrix remodeling, the exosomal release of pro-oncogenic factors as well as the induction of epithelial-me

SUBMITTER: Scioli MG 

PROVIDER: S-EPMC6651808 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature