L1TD1 - a prognostic marker for colon cancer.

ABSTRACT:

Background

Prognostic markers specific to a particular cancer type can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities.

Methods

Gene expression data was analyzed from three independent colon cancer microarray gene expression data sets (N = 1052). Survival analysis was performed for the three data sets, stratified by the expression level of the LINE-1 type transposase domain containing 1 (L1TD1). Correlation analysis was performed to investigate the role of the interactome of L1TD1 in colon cancer patients.

Results

We found L1TD1 as a novel positive prognostic marker for colon cancer. Increased expression of L1TD1 associated with longer disease-free survival in all the three data sets. Our re

SUBMITTER: Chakroborty D 

PROVIDER: S-EPMC6651905 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature