Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice.

ABSTRACT:

Background

Obesity is a chronic and systemic inflammatory disorder and an important risk factor for the onset of several chronic syndromes. Adipose tissue (AT) plays a crucial role in the development of obesity, promoting the infiltration and accumulation of leukocytes in the tissue and sustaining adipocyte expansion. Anthocyanins exert a broad range of health benefits, but their effect in improving obesity-related inflammation in vivo has been poorly characterized. We examined the effects of a purple corn cob extract in the context of AT inflammation in a murine diet-induced obesity (DIO) model.

Methods

Male C57BL/6J mice were subjected to control diet (CTR + H₂O), high fat diet (HF + H₂O) or high fat diet plus purple corn extract (HF + RED) for 12 wee

SUBMITTER: Tomay F 

PROVIDER: S-EPMC6651915 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature