Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways.

ABSTRACT:

Background

Breast cancer currently is the most frequently diagnosed neoplasm and the leading cause of death from cancer in women worldwide, which is mainly due to metastatic disease. Increasing our understanding of the molecular mechanisms leading to metastasis might thus improve the pharmacological management of the disease. Epithelial-mesenchymal transition (EMT) is a key factor that plays a major role in tumor metastasis. Some pro-inflammatory cytokines, like IL-6, have been shown to stimulate phenotypes consistent with EMT in transformed epithelial cells as well as in carcinoma cell lines. Since the EMT is one of the crucial steps for metastasis, we studied the effects of metformin (MTF) on EMT.

Methods

Cytotoxic effect of MTF was evaluated in eight primary breast cancer

SUBMITTER: Esparza-Lopez J 

PROVIDER: S-EPMC6651945 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature