A single-arm pilot study of metformin in patients with autosomal dominant polycystic kidney disease.

ABSTRACT:

Background

Metformin has shown promising results regarding cystogenesis inhibition in preclinical studies with autosomal dominant polycystic kidney disease (ADPKD) models. We designed a prospective, preliminary, single-arm study to evaluate the tolerability, safety and the effect of Metformin on kidney function and body mass index (BMI) in Romanian patients with ADPKD.

Methods

We enrolled 34 adult patients with ADPKD, chronic kidney disease (CKD) stages 1-5 not on dialysis and without diabetes mellitus. The primary endpoint was to assess the tolerability and safety of Metformin. The secondary endpoints evaluated changes in estimated glomerular filtration rate (eGFR), body mass index (BMI) and renal replacement therapy (RRT) necessity. Patients received an initial dose of Met

SUBMITTER: Sorohan BM 

PROVIDER: S-EPMC6651959 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature