Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis.

ABSTRACT:

Background

Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts showed potent in vitro antibacterial activity. However, the antibacterial components are unknown.

Methods

In this study, the stem bark of the CG plant was extracted and its antibacterial property against a panel of Gram-negative and Gram-positive bacterial strains assessed using the disk diffusion assay method. Bioassay-guided fractionation of the bioactive extracts was employed to identify bioactive constituents using both gas and liquid chromatography mass spectrometry. Chemical synthesis was used to make the analogues of gallic acid. Microplate dilution as

SUBMITTER: Aldulaimi O 

PROVIDER: S-EPMC6651987 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature