A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources.

ABSTRACT: Exposure- and risk-based assessments for chemicals used indoors or applied to humans (i.e., in near-field environments) necessitate an aggregate exposure pathway framework that aligns chemical exposure information from use sources to internal dose and eventually to their potential for health effects. Such a source-to-effect continuum is advocated to balance the complexity of human exposure and the insufficiency of relevant data for thousands of existing and emerging chemicals. Here, we introduce the Risk Assessment, IDentification And Ranking-Indoor and Consumer Exposure (RAIDAR-ICE) model, which establishes an integrated framework to evaluate human exposure due to indoor use and direct application of chemicals to humans. As a model evaluation, RAIDAR-ICE faithfully reproduces exposure est

SUBMITTER: Li L 

PROVIDER: S-EPMC6652188 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature