Improving Estimates of Compensatory cis-trans Regulatory Divergence.

ABSTRACT: Interspecific hybrids have played a key role in research on gene expression regulation. A growing number of studies have measured genome-wide allele-specific expression in hybrids and observed that cis-regulatory changes often oppose trans-acting changes affecting the same genes, suggesting stabilizing selection for compensatory changes. However, the most common method for estimating these effects is biased, producing artifactual patterns of compensatory evolution. Here I introduce a simple modification leveraging biological replicates that ameliorates the bias.

SUBMITTER: Fraser HB 

PROVIDER: S-EPMC6652221 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature