Identification of Protective CD8 T Cell Responses in a Mouse Model of Zika Virus Infection.

ABSTRACT: Many flaviviruses including dengue (DENV), and Zika (ZIKV) have attracted significant attention in the past few years. As many flaviviruses are spread by arthropods, most of the world's population is at risk of encountering a flavivirus, and infection with these viruses has created a significant disease burden worldwide. Vaccination against flaviviruses is thought to be one of the most promising avenues for reducing the disease burden associated with these viruses. The optimism surrounding a vaccine approach is supported by the highly successful vaccines for yellow fever and Japanese encephalitis. Central to the development of new successful vaccines is the understanding of the correlates of protection that will be necessary to engineer into new vaccines. To aid in this endeavor we have di

SUBMITTER: Hassert M 

PROVIDER: S-EPMC6652237 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature