Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model.

ABSTRACT: Endometriosis is an oestrogen-dependent, inflammation-driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up-regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long-term clinical use. An endometriosis-targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens p

SUBMITTER: Pluchino N 

PROVIDER: S-EPMC6653393 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature