Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages.

ABSTRACT: Progressive generation of total joint implant-derived wear particles is one of the major risk factors in development of peri-prosthetic osteolysis especially in the aging society. It is commonly accepted that macrophages predominantly drive the inflammatory response to wear debris particles. Among various surface receptors that activate the macrophages to phagocytize particles, it is believed that the Toll-like receptor 4 (TLR4) and the scavenger macrophage receptor with collagenous structure (MARCO) play key roles in recognition of wear debris particles. However, a strong body of evidence indicates an age-dependent diminished function of human TLRs. Thus, we hypothesized that the MARCO receptor may be more engaged than TLRs in the phagocytosis of wear debris particles which in turn up-reg

SUBMITTER: Yamada C 

PROVIDER: S-EPMC6653467 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature