Naturally acquired immunity against immature <i>Plasmodium falciparum</i> gametocytes.

ABSTRACT: The recent decline in global malaria burden has stimulated efforts toward Plasmodium falciparum elimination. Understanding the biology of malaria transmission stages may provide opportunities to reduce or prevent onward transmission to mosquitoes. Immature P. falciparum transmission stages, termed stages I to IV gametocytes, sequester in human bone marrow before release into the circulation as mature stage V gametocytes. This process likely involves interactions between host receptors and potentially immunogenic adhesins on the infected red blood cell (iRBC) surface. Here, we developed a flow cytometry assay to examine immune recognition of live gametocytes of different developmental stages by naturally exposed Malawians. We identified strong antibody recognition of the earli

SUBMITTER: Dantzler KW 

PROVIDER: S-EPMC6653583 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature