Impact of standard care on elderly glioblastoma patients.

ABSTRACT:

Background

Uncertainty persists about the survival advantage of concomitant and adjuvant temozolomide (TMZ) plus radiotherapy (RT) in elderly patients with newly diagnosed glioblastoma (GBM). We compared the clinical outcome of unselected elderly GBM patients treated with 4 adjuvant treatment modalities, including the Stupp protocol.

Methods

From 2010 to 2014, retrospective chart review was performed on 171 GBM patients aged ≥55 who received either concurrent chemoradiation therapy (CCRT) with standard 60 Gy/30 (SRT); CCRT with hypofractionated 40 Gy/15 (HRT); HRT alone; or TMZ alone. Stratification is by age (55-69, ≥70), KPS (<70, ≥70), and resection status (biopsy, resection).

Results

Out of 171 patients identified, 128(75%) had surgical resection, median ag

SUBMITTER: Lapointe S 

PROVIDER: S-EPMC6655425 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature