Deconstructing Bipolar Disorder and Schizophrenia: A cross-diagnostic cluster analysis of cognitive phenotypes.

ABSTRACT:

Background

Bipolar disorder (BD) and schizophrenia (SZ) show substantial overlap. It has been suggested that a subgroup of patients might contribute to these overlapping features. This study employed a cross-diagnostic cluster analysis to identify subgroups of individuals with shared cognitive phenotypes.

Method

143 participants (68 BD patients, 39 SZ patients and 36 healthy controls) completed a battery of EEG and performance assessments on perception, nonsocial cognition and social cognition. A K-means cluster analysis was conducted with all participants across diagnostic groups. Clinical symptoms, functional capacity, and functional outcome were assessed in patients.

Results

A two-cluster solution across 3 groups was the most stable. One cluster including 44 BD pat

SUBMITTER: Lee J 

PROVIDER: S-EPMC6655479 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature