Association of genetic variants with fatigue in patients with malignant glioma.

ABSTRACT:

Background

Fatigue is a consistently reported, severe symptom among patients with gliomas throughout the disease trajectory. Genomic pathways associated with fatigue in glioma patients have yet to be identified.

Methods

Clinical factors (performance status, tumor details, age, gender) were collected by chart review on glioma patients with fatigue ("I have lack of energy" on Functional Assessment of Cancer Therapy-Brain), as well as available genotyping data. Candidate genes in clock and inflammatory pathways were identified from a literature review, of which 50 single nucleotide polymorphisms (SNPs) in 7 genes were available. Clinical factors and SNPs identified by univariate analyses were included in a multivariate model for moderate-severe fatigue.

Results

The study

SUBMITTER: Armstrong TS 

PROVIDER: S-EPMC6655500 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature