FMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder.

ABSTRACT: Functional magnetic resonance imaging (fMRI) adaptation (also known as fMRI repetition suppression) has been widely used to characterize stimulus selectivity in vivo, a fundamental feature of neuronal processing in the brain. We investigated whether SZ patients and BD patients show aberrant fMRI adaptation for object perception. About 52 SZ patients, 55 BD patients, and 53 community controls completed an object discrimination task with three conditions: the same object presented twice, two exemplars from the same category, and two exemplars from different categories. We also administered two functional localizer tasks. A region of interest analysis was employed to evaluate a priori hypotheses about the lateral occipital complex (LOC) and early visual cortex (EVC). An exploratory whole brai

SUBMITTER: Lee J 

PROVIDER: S-EPMC6655550 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature