Report of first recurrent glioma patients examined with PET-MRI prior to re-irradiation.

ABSTRACT:

Background and purpose

The advantage of combined PET-MRI over sequential PET and MRI is the high spatial conformity and the absence of time delay between the examinations. The benefit of this technique for planning of re-irradiation (re-RT) treatment is unkown yet. Imaging data from a phase 1 trial of re-RT for recurrent glioma was analysed to assess whether planning target volumes and treatment margins in glioma re-RT can be adjusted by PET-MRI with rater independent PET based biological tumour volumes (BTVs).

Patients and methods

Combined PET-MRI with the tracer O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) prior to re-RT was performed in recurrent glioma patients in a phase I trial. GTVs including all regions suspicious of tumour on contrast enhanced MRI were delineated by t

SUBMITTER: Fleischmann DF 

PROVIDER: S-EPMC6655559 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature