Genome-wide SNP analysis of Japanese Thoroughbred racehorses.

ABSTRACT: The domestication process of plants and animals typically involves intense inbreeding and directional selection for various traits. Here, we genotyped 370 Japanese Thoroughbred horses using the recently developed 670k SNP array and performed various genome-wide analysis also using genotype data of other horse breeds. We identified a number of regions showing interesting patterns of polymorphisms. For instance, the region containing the MC1R locus associated with chestnut coat color may have been targeted by selection for a different mutation much earlier on than the recent selection for chestnut color. We also identified regions that show signatures of selection specific to Thoroughbreds. In addition, we found that intense inbreeding early in the history of the Thoroughbred breed and also

SUBMITTER: Fawcett JA 

PROVIDER: S-EPMC6655603 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature