The effects of sildenafil in maternal and fetal outcomes in pregnancy: A systematic review and meta-analysis.

ABSTRACT:

Background

The number of studies associating the use of sildenafil in gestation is increasing. This drug inhibits phosphodiesterase type 5 (PDE5), an enzyme responsible for degradation of nitric oxide, and its efficacy is greater in the placental territory, as the maternal side of the placenta have more PDE5 than other sites. For this reason, promising results have been observed related to the prevention of preeclampsia and intrauterine growth restriction and to improvement of maternal-fetal morbidity in cases of placental insufficiency.

Objective

To evaluate the benefits of using sildenafil in pregnancy.

Searched strategy

MEDLINE, ClinicalTrials.gov, Embase, LILACS and Cochrane databases were searched through September 2018. There was no restriction in language or ye

SUBMITTER: Ferreira RDDS 

PROVIDER: S-EPMC6655684 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature