Control of neural probe shank flexibility by fluidic pressure in embedded microchannel using PDMS/PI hybrid substrate.

ABSTRACT: Implantable neural probes are widely used to record and stimulate neural activities. These probes should be stiff enough for insertion. However, it should also be flexible to minimize tissue damage after insertion. Therefore, having dynamic control of the neural probe shank flexibility will be useful. For the first time, we have successfully fabricated flexible neural probes with embedded microfluidic channels for dynamic control of neural probe stiffness by controlling fluidic pressure in the channels. The present hybrid neural probes consisted of polydimethylsiloxane (PDMS) and polyimide (PI) layers could provide the required stiffness for insertion and flexibility during operation. The PDMS channels were fabricated by reversal imprint using a silicon mold and bonded to a PI layer to for

SUBMITTER: Rezaei S 

PROVIDER: S-EPMC6655783 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature