Survival impact of prolonged postoperative radiation therapy for patients with glioblastoma treated with combined-modality therapy.

ABSTRACT:

Background

Though conventionally fractionated chemoradiation (CRT) is well tolerated by selected patients with newly diagnosed glioblastoma (GBM), adverse health-related and nonhealth-related factors can lead to unplanned interruptions in treatment. The effects of prolonged time to completion (TTC) of radiation therapy (RT) on overall survival (OS) for these patients are unclear.

Methods

The National Cancer Database (NCDB) was queried for all adult patients with newly diagnosed GBM undergoing surgical resection followed by adjuvant CRT with conventionally fractionated RT (6000-6600 cGy in 30-33 fractions) from 2005 to 2012. TTC was defined as the interval from first to last fraction of RT. Recursive partitioning analysis (RPA) was used to determine a threshold for TTC of adj

SUBMITTER: Yusuf MB 

PROVIDER: S-EPMC6656316 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature