A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia.

ABSTRACT: We examined longitudinal change in language expression during a semi-structured speech sample in 48 patients with primary progressive aphasia (PPA) or behavioral variant frontotemporal dementia (bvFTD) and related this to longitudinal neuroimaging of cortical thickness available in 25 of these patients. All patient groups declined significantly on measures of both speech fluency and grammar, although patients with nonfluent/agrammatic PPA (naPPA) declined to a greater extent than patients with the semantic variant, the logopenic variant, and bvFTD. These patient groups also declined on several neuropsychological measures, but there was no correlation between decline in speech expression and decline in neuropsychological performance. Longitudinal decline in grammaticality, assessed by the n

SUBMITTER: Ash S 

PROVIDER: S-EPMC6656376 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature