Targeting the CBM complex causes T_reg cells to prime tumours for immune checkpoint therapy.

ABSTRACT: Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (T_reg) cells that restrict the function of effector T cells and thereby promote tumour growth¹. The anti-tumour activity of effector T cells can be therapeutically unleashed, and is now being exploited for the treatment of some forms of human cancer. However, weak tumour-associated inflammatory responses and the immune-suppressive function of T_reg cells remain major hurdles to broader effectiveness of tumour immunotherapy². Here we show that, after disruption of the CARMA1-BCL10-MALT1 (CBM) signalosome complex, most tumour-infiltrating T_reg cells produce IFNγ, resulting in stunted tumour growth. Notably, genetic de

SUBMITTER: Di Pilato M 

PROVIDER: S-EPMC6656391 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature