Investigation of Glycosyl Nitrates as Building Blocks for Chemical Glycosylation.

ABSTRACT: Glycosyl nitrates are important synthetic intermediates in the synthesis of 2-amino sugars, 1,2-orthoesters or, more recently, 2-OH glucose. However, glycosyl nitrates have never been glycosidated. Presented herein is our first attempt to use glycosyl nitrates as glycosyl donors for O-glycosylation. Lanthanide triflates showed good affinity to activate the nitrate leaving group.

SUBMITTER: Wang T 

PROVIDER: S-EPMC6656396 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature