Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England.

ABSTRACT: Adrenal insufficiency and Cushing's syndrome are known adverse events of glucocorticoids. However, no population estimates of dose-related risks are available. To investigate dose-related risks of adrenal dysfunction and death in adults with six chronic inflammatory diseases treated with oral glucocorticoids. Retrospective record-linkage open-cohort study spanning primary and hospital care in England. 70,638 people oral glucocorticoid-users and 41,166 non-users aged ≥18 years registered in 389 practices in 1998-2017. Incidence rates and hazard ratios (HRs) of diagnosed adrenal dysfunction and death. During a median follow-up of 5.5 years, 183 patients had glucocorticoid-induced adrenal insufficiency and 248 glucocorticoid-induced Cushing's syndrome. A total of 22,317 (31.6%) and 7,544 (18.

SUBMITTER: Mebrahtu TF 

PROVIDER: S-EPMC6656418 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature