Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs.

ABSTRACT: Vitamin D may be important for prenatal programming of insulin and glucose regulation, but maternal vitamin D deficiency during pregnancy is common. We examined associations of early vitamin D status with markers of fetal insulin secretion (cord blood insulin and c-peptide). We hypothesized that maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy and cord blood 25(OH)D would both be positively associated with cord blood insulin and c-peptide. We studied mother-newborn pairs from two cohorts: Project Viva (862 pairs included) and Genetics of Glucose Regulation in Gestation and Growth (Gen3G, 660 pairs included). We analyzed associations of the cord blood hormones with maternal 25(OH)D using generalized additive models with nonlinear spline terms and with cord blood 25(OH)D using multiva

SUBMITTER: Switkowski KM 

PROVIDER: S-EPMC6656419 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature