Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients.

ABSTRACT:

Purpose

The ability to predict and detect clinical and subclinical nephrotoxicity early in the course of therapy has the potential to improve long-term outcomes in cancer patients receiving cisplatin chemotherapy. Pharmacokinetic parameters could serve as predictors of cisplatin-induced nephrotoxicity.

Methods

Participants [n = 13] were treated with a 1-h cisplatin infusion [30-75 mg/m²]. Blood was collected pre-dose and up to 6 h post-dose. Urinary biomarkers [KIM-1, calbindin, clusterin, GST-pi, β2M, albumin, NGAL, osteopontin, clusterin, MCP-1, cystatin C, and TFF3] were measured at baseline, days 3 and 10. Total and unbound platinum concentrations were measured using ICP/MS. Noncompartmental analysis was performed, and correlation and regression analyses evalu

SUBMITTER: Ibrahim ME 

PROVIDER: S-EPMC6656531 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature