Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs.

ABSTRACT:

Objective

To assess the association between exposure to monotherapy with 10 different antiepileptic drugs (AEDs) during the first 2 months of pregnancy and the risk of 23 major congenital malformations (MCMs).

Methods

This nationwide cohort study, based on the French health care databases, included all pregnancies ≥20 weeks and ending between January 2011 and March 2015. Women were considered to be exposed when an AED had been dispensed between 1 month before and 2 months after the beginning of pregnancy. The reference group included pregnant women with no reimbursement for AEDs. MCMs were detected up to 12 months after birth (24 months for microcephaly, hypospadias, and epispadias). Odds ratios (ORs) were adjusted for potential confounders for MCMs with at least 5 cases. Ot

SUBMITTER: Blotiere PO 

PROVIDER: S-EPMC6656651 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature