Epilepsy duration and seizure outcome in epilepsy surgery: A systematic review and meta-analysis.

ABSTRACT:

Objective

To conduct a systematic review and meta-analysis on the effect of earlier or later resective epilepsy surgery on seizure outcome.

Methods

We searched the electronic databases PubMed, EMBASE, and Cochrane Library for studies investigating the association of epilepsy duration and seizure freedom after resective surgery. Two reviewers independently screened citations for eligibility and assessed relevant studies for risk of bias. We combined data in meta-analyses using a random effects model. We assessed the certainty of evidence according to Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Results

Twenty-five studies were included, 12 of which had data suitable for meta-analyses. Comparing seizure outcome if epilepsy surgery was perfo

SUBMITTER: Bjellvi J 

PROVIDER: S-EPMC6656653 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature