Study on gene expression patterns and functional pathways of peripheral blood monocytes reveals potential molecular mechanism of surgical treatment for periodontitis.

ABSTRACT:

Background

Periodontitis is a chronic inflammation of periodontal supporting tissue caused by local factors. Periodontal surgery can change the gene expression of peripheral blood mononuclear cells. However, little is known about the potential mechanism of surgical treatment for periodontitis.

Aim

To explore the potential molecular mechanism of surgical treatment for periodontitis.

Methods

First, based on the expression profiles of genes related to surgical treatment for periodontitis, a set of expression disorder modules related to surgical treatment for periodontitis were obtained by enrichment analysis. Subsequently, based on crosstalk analysis, we proved that there was a significant crosstalk relationship between module 3 and module 5. Finally, based on predictive

SUBMITTER: Ma JJ 

PROVIDER: S-EPMC6656668 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature