Breast Cancer Classification Based on Proteotypes Obtained by SWATH Mass Spectrometry.

ABSTRACT: Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical fragment ion spectra (SWATH) mass spectrometry and establish key proteins for breast tumor classification. The study is based on 96 tissue samples representing five conventional breast cancer subtypes. SWATH proteotype patterns largely recapitulate these subtypes; however, they also reveal varying heterogeneity within the conventional subtypes, with triple negative tumors being the most heterogeneous. Proteins that contribute most strongly to the proteotype-based classification include INPP4B, CDK1, and ERBB2 and are associated with estrogen receptor (ER

SUBMITTER: Bouchal P 

PROVIDER: S-EPMC6656695 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature