EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming.

ABSTRACT: Memory CD8⁺ T cells have the ability to provide lifelong immunity against pathogens. Although memory features generally arise after challenge with a foreign antigen, naïve CD8 single positive (SP) thymocytes may acquire phenotypic and functional characteristics of memory cells in response to cytokines such as interleukin-4. This process is associated with the induction of the T-box transcription factor Eomesodermin (EOMES). However, the underlying molecular mechanisms remain ill-defined. Using epigenomic profiling, we show that these innate memory CD8SP cells acquire only a portion of the active enhancer repertoire of conventional memory cells. This reprograming is secondary to EOMES recruitment, mostly to RUNX3-bound enhancers. Furthermore, EOMES is found within chromatin-assoc

SUBMITTER: Istaces N 

PROVIDER: S-EPMC6656725 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature