Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to ⁶⁸Ga-PSMA PET-CT.

ABSTRACT: The aim was to assess the performance of prostate 3T MRI for pelvic lymph node (LN) staging in prostate cancer (PCa), in comparison to ⁶⁸Gallium-prostate specific membrane antigen PET-CT (⁶⁸Ga-PSMA PET-CT) as reference standard for LN detection. 130 patients with PCa underwent non-contrast-enhanced multiparametric prostate 3T MRI and ⁶⁸Ga-PSMA-PET-CT within 180 days at our institution. Overall, 187 LN metastases (n = 43 patients) detected by ⁶⁸Ga-PSMA-PET-CT were characterized by calculating maximum standardized uptake value (SUVmax), area, diameter and anatomical location including iliac, obturator, presacral and inguinal region. MRI achieved an overall sensitivity, specificity, positive and negative predictive value of 81.6% (CI 71.1-88.9%), 98

SUBMITTER: Meißner S 

PROVIDER: S-EPMC6656738 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature