Ontology highlight
ABSTRACT:
SUBMITTER: Ishii J
PROVIDER: S-EPMC6656751 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20190724
Iodide transport and storage in the thyroid follicles is crucial for thyroid hormone synthesis. Pendrin, the iodide exporter that transports iodide to thyroid follicles, is responsible for Pendred syndrome, a disorder characterized by congenital hypothyroidism and hearing loss. However, thyroid hormone levels are basically normal in patients with Pendred syndrome, indicating the presence of another unknown iodide transporter. Here, we show that SLC26A7 is a novel iodide transporter in the thyroi ...[more]