Soluble and membrane-bound protein carrier mediate direct copper transport to the ethylene receptor family.

ABSTRACT: The plant hormone ethylene is a key regulator of plant growth, development and stress adaption. Ethylene perception and response are mediated by a family of integral membrane receptors (ETRs) localized at the ER-Golgi network. The biological function of these receptors relies on a protein-bound copper cofactor. Nonetheless, molecular processes and structures controlling assembly and integration of the metal into the functional plant hormone receptor are still unknown. Here, we have explored the molecular pathways of copper transfer from the plant cytosol to the ethylene receptor family by analyzing protein-protein interactions of receptors with soluble and membrane-bound plant copper carriers. Our results suggest that receptors primarily acquire their metal cofactor from copper transporter

SUBMITTER: Hoppen C 

PROVIDER: S-EPMC6656775 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature