Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study.

ABSTRACT:

Background

Most tuberculosis-related deaths in people with HIV could be prevented with earlier diagnosis and treatment. The only commercially available tuberculosis point-of-care test (Alere Determine TB LAM Ag [AlereLAM]) has suboptimal sensitivity, which restricts its use in clinical practice. The novel Fujifilm SILVAMP TB LAM (FujiLAM) assay has been developed to improve the sensitivity of AlereLAM. We assessed the diagnostic accuracy of the FujiLAM assay for the detection of tuberculosis in hospital inpatients with HIV compared with the AlereLAM assay.

Methods

For this diagnostic accuracy study, we assessed biobanked urine samples obtained from the FIND Specimen Bank and the University of Cape Town Biobank, which had been collected from hospital inpatients (aged ≥18 year

SUBMITTER: Broger T 

PROVIDER: S-EPMC6656794 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature