Rats that are predisposed to excessive obesity show reduced (leptin-induced) thermoregulation even in the preobese state.

ABSTRACT: Both feeding behavior and thermogenesis are regulated by leptin. The sensitivity to leptin's anorexigenic effects on chow diet was previously shown to predict the development of diet-induced obesity. In this study, we determined whether the sensitivity to leptin's anorexigenic effects correlates with leptin's thermogenic response, and if this response is exerted at the level of the dorsomedial hypothalamus (DMH), a brain area that plays an important role in thermoregulation. Based on the feeding response to injected leptin on a chow diet, rats were divided into leptin-sensitive (LS) and leptin-resistant (LR) groups. The effects of leptin on core body, brown adipose tissue (BAT) and tail temperature were compared after intravenous versus intra-DMH leptin administration. After intravenous le

SUBMITTER: de Git KCG 

PROVIDER: S-EPMC6656864 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature