Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia.

ABSTRACT: Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders, and more and more multicomponent drugs represented by traditional Chinese medicines have provided a favorable therapeutic effect in its treatment. However, their precise localization in the clinic, as well as corresponding mechanism, is ambiguous, thus hindering their widespread use. To meet this requirement, a precise and systematic approach based on a restriction of special disease-related molecules and the following network pharmacology analysis was developed and applied to a multicomponent conventional drug, XiaoErFuPi (XEFP) granules. Experimental verification of the results indicates that this approach can facilitate the prediction, and the precise and systematic efficacy of XEFP could be ea

SUBMITTER: Wei J 

PROVIDER: S-EPMC6656888 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature