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Synthesis of ynones at room temperature catalyzed by copper chloride cryptand complex under solvent free conditions.

ABSTRACT: An air-stable highly efficient reusable CuCl₂-cryptand-[2.2.Benzo] catalyst is reported first time for coupling reaction of terminal alkynes with different acyl chlorides in the presence of triethylamine acting both as base and solvent at room temperature to give the corresponding ynones. Easy-going, short reaction time, cost-effective, palladium-, phosphorus- and solvent-free, high yield and recyclability up to 5^th times make this method green procedure for ynones' synthesis with wide substrate variety.

SUBMITTER: Bora SJ

PROVIDER: S-EPMC6656957 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Synthesis of ynones at room temperature catalyzed by copper chloride cryptand complex under solvent free conditions.

Bora Sankar Jyoti SJ Chetia Bolin B

Heliyon 20190719 7

An air-stable highly efficient reusable CuCl2-cryptand-[2.2.Benzo] catalyst is reported first time for coupling reaction of terminal alkynes with different acyl chlorides in the presence of triethylamine acting both as base and solvent at room temperature to give the corresponding ynones. Easy-going, short reaction time, cost-effective, palladium-, phosphorus- and solvent-free, high yield and recyclability up to 5th times make this method green procedure for ynones' synthes ...[more]

PMID: 31372526

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