Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis.

ABSTRACT:

Background

The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to capillary leak and organ dysfunction. Moreover, sepsis-induced alterations of sublingual microcirculation are associated with a worse clinical outcome. The present study was performed to investigate the associations between eGC dimensions and established parameters of microcirculation dysfunction in sepsis.

Methods

This observational, prospective, cross-sectional study included 40 participants, of which 30 critically ill septic patients were recruited from intensive care units of a university hospital and 10 healthy volunteers served as controls. The establi

SUBMITTER: Rovas A 

PROVIDER: S-EPMC6657098 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature