The contribution of miR-122 to the innate immunity by regulating toll-like receptor 4 in hepatoma cells.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a kind of malignancies to impact human health. It has been reported that aberrant toll-like receptor (TLR) signaling may contribute to the development and progression of HCC, especially TLR4. MiR-122, which extensively involved in hepatitis virus infection and the apoptosis of hepatoma cells, might be decreased in HCC patients livers. The hypothesis of this study was whether miR-122 plays a role in inflammatory pathways through regulating TLR4 expression in hepatoma cells.

Methods

The expression of miR-122 in the tissues of HCC patients compared to controls in TCGA datasets was analyzed. The relationship between miR-122 and TLR4 was detected in HCC cell lines by increasing/decreasing miR-122 expression. The target of miR-122 on TL

SUBMITTER: Shi L 

PROVIDER: S-EPMC6657172 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature