Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model.

ABSTRACT:

Background

Complement factor C5 can either aggravate or attenuate the T-helper type 2 (T_H2) immune response and airway hyperresponsiveness (AHR) in murine models of allergic asthma. The effect of C5 during the effector phase of allergen-induced asthma is ill-defined.

Objectives

We aimed to determine the effect of C5 blockade during the effector phase on the pulmonary T_H2 response and AHR in a house dust mite (HDM) driven murine asthma model.

Methods

BALB/c mice were sensitized and challenged repeatedly with HDM via the airways to induce allergic lung inflammation. Sensitized mice received twice weekly injections with a blocking anti-C5 or control antibody 24 h before the first challenge.

Results

HDM challenge in sensitized mice resulted in

SUBMITTER: Yang J 

PROVIDER: S-EPMC6657208 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature