Prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in older adults.

ABSTRACT:

Aims

Non-ischaemic cardiomyopathies (NICM) can cause heart failure and death. Cardiac magnetic resonance (CMR) detects myocardial scar/fibrosis associated with myocardial infarction (MI) and NICM with late gadolinium enhancement (LGE). The aim of this study was to determine the prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in a community-based sample of older adults.

Methods and results

The ICELAND-MI cohort, a substudy of the Age, Gene/Environment Susceptibility Reykjavik (AGES-Reykjavik) study, provided a well-characterized population of 900 subjects after excluding subjects with pre-existing heart failure. Late gadolinium enhancement CMR divided subjects into four groups: MI (n = 211), major (n = 54) non-ischaemic fibrosis (well-established,

SUBMITTER: Shanbhag SM 

PROVIDER: S-EPMC6657269 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature