Cellular Compartmentation and the Redox/Nonredox Functions of NAD^.

ABSTRACT: Significance: Nicotinamide adenine dinucleotide (NAD⁺) spans diverse roles in biology, serving as both an important redox cofactor in metabolism and a substrate for signaling enzymes that regulate protein post-translational modifications (PTMs). Critical Issues: Although the interactions between these different roles of NAD⁺ (and its reduced form NADH) have been considered, little attention has been paid to the role of compartmentation in these processes. Specifically, the role of NAD⁺ in metabolism is compartment specific (e.g., mitochondrial vs. cytosolic), affording a very different redox landscape for PTM-modulating enzymes such as sirtuins and poly(ADP-ribose) polymerases in different cell compartments. In addi

SUBMITTER: Kulkarni CA 

PROVIDER: S-EPMC6657305 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature