Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here.

ABSTRACT: The National Toxicology Program (NTP) receives requests to evaluate chemicals with potential to cause adverse health effects, including developmental neurotoxicity (DNT). Some recent requests have included classes of chemicals such as flame retardants, polycyclic aromatic compounds, perfluoroalkyl substances, and bisphenol A analogs with approximately 20-50 compounds per class, many of which include commercial mixtures. However, all the compounds within a class cannot be tested using traditional DNT animal testing guideline studies due to resource and time limitations. Hence, a rapid and biologically relevant screening approach is required to prioritize compounds for further in vivo testing. Because neurodevelopment is a complex process involving multiple distinct cellular processes, one a

SUBMITTER: Behl M 

PROVIDER: S-EPMC6657567 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature