Multi-Behavioral Endpoint Testing of an 87-Chemical Compound Library in Freshwater Planarians.

ABSTRACT: There is an increased recognition in the field of toxicology of the value of medium-to-high-throughput screening methods using in vitro and alternative animal models. We have previously introduced the asexual freshwater planarian Dugesia japonica as a new alternative animal model and proposed that it is particularly well-suited for the study of developmental neurotoxicology. In this article, we discuss how we have expanded and automated our screening methodology to allow for fast screening of multiple behavioral endpoints, developmental toxicity, and mortality. Using an 87-compound library provided by the National Toxicology Program, consisting of known and suspected neurotoxicants, including drugs, flame retardants, industrial chemicals, polycyclic aromatic hydrocarbons (PAHs), pesticides

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6657585 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature