Identifying the Critical Factors Governing Translaminar Pressure Differential Through a Compartmental Model.

ABSTRACT:

Purpose

The effective management of glaucoma is hindered by an incomplete understanding of its pathologic mechanism. While important, intraocular pressure (IOP) alone is inadequate in explaining glaucoma. Non-IOP-mediated risk factors such as cerebrospinal fluid (CSF) pressure have been reported to contribute to glaucomatous optic neuropathy. Due to the difficulty associated with experimental measurement of the salient variables, such as the retrobulbar CSF pressure, porosity of the subarachnoid space (SAS), and especially those concerned with the perioptic SAS, there remains a limited understanding of the CSF behavior contributing to the translaminar pressure gradient (TLPG), hypothesized to be a critical factor in the development of glaucoma.

Method

An integrated compartme

SUBMITTER: Kaskar OG 

PROVIDER: S-EPMC6657705 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature