Regulation of Pseudomonas aeruginosa-Mediated Neutrophil Extracellular Traps.

ABSTRACT: Pseudomonas aeruginosa is the most prevalent opportunistic pathogen in the airways of cystic fibrosis (CF) patients. The pulmonary disorder is characterized by recurrent microbial infections and an exaggerated host inflammatory immune response led primarily by influx of neutrophils. Under these conditions, chronic colonization with P. aeruginosa is associated with diminished pulmonary function and increased morbidity and mortality. P. aeruginosa has a wide array of genetic mechanisms that facilitate its persistent colonization of the airway despite extensive innate host immune responses. Loss of function mutations in the quorum sensing regulatory gene lasR have been shown to confer survival advantage and a more pathogenic character to P. aeruginosa in CF

SUBMITTER: Skopelja-Gardner S 

PROVIDER: S-EPMC6657737 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature