Cost and efficacy comparison of prenatal recall and reflex DNA screening for trisomy 21, 18 and 13.

ABSTRACT:

Objective

To compare costs and efficacy of reflex and recall prenatal DNA screening for trisomy 21, 18 and 13 (affected pregnancies). In both methods women have Combined test markers measured. With recall screening, women with a high Combined test risk are recalled for counselling and offered a DNA blood test or invasive diagnostic testing. With reflex screening, a DNA analysis is automatically performed on plasma collected when blood was collected for measurement of the Combined test markers.

Methods

Published data were used to estimate, for each method, using various unit costs and risk cut-offs, the cost per woman screened, cost per affected pregnancy diagnosed, and for a given number of women screened, numbers of affected pregnancies diagnosed, unaffected pregnancies wit

SUBMITTER: Bestwick JP 

PROVIDER: S-EPMC6658079 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature