Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review.

ABSTRACT:

Background & aims

A comprehensive knowledge of the natural history of ulcerative colitis (UC) helps understand disease evolution, identify poor prognostic markers and impact of treatment strategies, and facilitates shared decision-making. We systematically reviewed the natural history of UC in adult population-based cohort studies with long-term follow-up.

Methods

Through a systematic literature review of MEDLINE through March 31, 2016, we identified 60 studies performed in 17 population-based inception cohorts reporting the long-term course and outcomes of adult-onset UC (n = 15,316 UC patients).

Results

Left-sided colitis is the most frequent location, and disease extension is observed in 10%-30% of patients. Majority of patients have a mild-moderate course, which i

SUBMITTER: Fumery M 

PROVIDER: S-EPMC6658168 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature